Acquiring and processing Raman spectral data for the C2-D stretching vibration of 2 deuterated histidine
We have recently reported the use of a deuterium label on the 2-carbon of histidine as a reporter of the protonation state of histidine, and possibly also as a reporter of histidine’s local environment. Implementation of this probe into proteins would provide an easy way to…Read Full Article
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Tip-Enhanced Raman Scattering (TERS)
![](https://www.princetoninstruments.com/wp-content/uploads/2020/04/TERS-clipped-exper-setup-Rasche.png)
The ability to identify small quantities of adsorbed analyte or structural features down to the few-molecule level is a key challenge in nanotechnology. Optical spectroscopy provides an attractive means to achieve such identification via non-invasive implementations and the potential for chemical sensitivity. Raman scattering has emerged as a particularly powerful technique due to its…Read Full Article