Prashant Jain
Nano Letters
Introduction
At the University of Minnesota, the lab of Sang-Hyun Oh is working on using nanotechnology and optical methods to advance analytical and sensing method in particular for bio and life science applications. They developed a high-resolution micro Raman spectroscopy system for fast measurements (the researchers talk about a factor 100x advantage in speed over similar systems) where the biological nano particles do not have to be labelled.
![](https://www.princetoninstruments.com/wp-content/uploads/2021/03/shutterstock_624720632-1024x683.jpg)
The team build microscopic traps for the nanoparticles using an effect called dielectrophoresis on plasmonic nanostructures. The traps capture the bio structures along a small gap that is imaged to a spectrograph so Raman spectra of all captured particles can be collected simultaneously. In addition to this multiplexing advantage gold nanoparticles are used to create a SERS surface enhanced Raman effect to obtain even stronger signals.
for real time monitoring of bio particles in cells. Having such a system will improve capabilities for cell and biological analysis and could lead to development of more capable biosensors.
![](https://www.princetoninstruments.com/wp-content/uploads/2022/01/isoplane-blaze-pixis-spectrapro-1024x224.png)